Bronchial Carcinoma Treated with Nitrogen Mustard and Cyclophosphamide.
نویسندگان
چکیده
Nitrogen mustard (mustine hydrochloride) has been used in the treatment of lung cancer for 20 years. Lynch, Ware, and Gaensler (1950), Kent and Reh (1950), Levine and Weisberger (1955), Hatch, Bradford, and Ochsner (1956), and Bass (1960) have described their experience with this cytotoxic agent and have reported symptomatic improvement in many patients, but little or no prolongation of life. Since 1958, when cyclophosphamide was synthesized, it has been widely used for malignant disease, including lung cancer, both palliatively in advanced inoperable disease (Spear and Patno, 1962; Braun-Wotke, 1963), and as cover for operation in patients with less-advanced disease (Poulsen, 1962, 1963).
منابع مشابه
Inappropriate antidiuretic hormone secretion in oat-cell carcinoma of bronchus. Aggravation of hyponatraemia by intravenous cyclophosphamide.
Hyponatraemia associated with bronchial carcinoma was first described by Winkler and Crankshaw (1938). Schwartz, Bennett, Curelop, and Bartter (1957) suggested that the hyponatraemia was due to 'inappropriate' secretion of antidiuretic hormone (ADH) by the tumour itself. Confirmation of this was provided by Lee, Jones, and Barraclough (1964) when a substance with an action resembling that of AD...
متن کاملThe effectiveness of cyclophosphamide (cytoxan) against well established transplanted rodent tumors.
The survival of mice and rats bearing well established transplanted carcinoma, leukemia, and lymphosarcoma was markedly extended by weekly doses of the cyclic phosphamide alkylating agent, Cytoxan. Complete regressions were obtained with four types of tumors. The activity of Cytoxan against these tumors was compared with the effects pre viously obtained with two other alkylating agents, uracil ...
متن کاملTreatment of bronchogenic carcinoma with nitrogen mustard.
There have been numerous reports as to the clinical results obtained with the chloroethylamines (nitrogen mustards) In the treatment of Hodgkin’s disease, lymphosarcoma and leukemia.’-11’9 There has been a paucity of reported clinical trials in regard to the treatment of bronchogenic carcinoma with nitrogen mustard despite the fact that a few cases of carcinoma of the lung treated with nitrogen...
متن کاملIsophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide.
Isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and ifosfamide against L1210 and P388 leukaemia. Lewis lung carcinoma, mammary adenocarcinoma 16/C, ovarian sarcoma M5076, and colon tumour 6A, in mice and Yoshida ascitic sarcoma in rats. At doses less than, or equivalent to, the LD10, isophosphoramide mustard retained high...
متن کاملPhenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients.
The 0-24-h urinary metabolic profile of cyclophosphamide was investigated in a series of 14 patients with various malignancies receiving combination chemotherapy including i.v. cyclophosphamide. This was accomplished using combined thin-layer chromatography-photography-densitometry, which can quantitate cyclophosphamide and its four principal urinary metabolites (4-ketocyclophosphamide, nor-nit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British medical journal
دوره 2 5463 شماره
صفحات -
تاریخ انتشار 1965